PPARγ, the ultimate thrifty gene
نویسندگان
چکیده
منابع مشابه
Insights from the developing world: thrifty genotypes and thrifty phenotypes.
Few researchers would dispute that the pandemic of obesity is caused by a profound mismatch between humanity's present environmental circumstances and those that have moulded evolutionary selection. This concept was first articulated when gestational diabetes was described as being the result of a 'thrifty genotype rendered detrimental by progress'. More recently, this hypothesis has been exten...
متن کاملThe "thrifty genotype" in 1998.
In 1962, under the title “Diabetes mellitus: A ‘thrifty’ genotype rendered detrimental by ‘progress’?,’’ I published the suggestion that the basic defect in diabetes mellitus was a quick insulin trigger.’ This was an asset to our tribal, hunter-gatherer ancestors with their intermittent, sometimes feast-or-famine alimentation, since it should have minimized renal loss of precious glucose. Curre...
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A universal construction is an algorithm which transforms any sequential implementation of an object into a concurrent implementation of that same object in a linearizable and wait-free manner. Such constructions require underlying low-level universal shared objects such as compare-and-swap and load-linked/store-conditional . In this paper, we present the first universal construction that (a) u...
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We study the complexity of one-dimensional extrema testing: given one input number, determine if it is properly contained in the interval spanned by the remaining n input numbers. We assume that each number is given as a finite stream of bits, in decreasing order of significance. Our cost measure, referred to as the leading-input-bits-cost (or LIB-cost for short), for an algorithm solving such ...
متن کاملThrifty Generic Broadcast
We consider the problem of generic broadcast in asynchronous systems with crashes a problem that was rst studied in Roughly speaking given a con ict relation on the set of messages generic broad cast ensures that any two messages that con ict are delivered in the same order messages that do not con ict may be delivered in di erent order In this paper we de ne what it means for an implementation...
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ژورنال
عنوان ژورنال: Diabetologia
سال: 1999
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250051268